Xenical
Orlistat 120mg (Branded)
by Roche
The original branded prescription orlistat — trusted by clinicians for over 25 years
10.6 kg
Average 1-year weight loss (clinical trials)
XENDOS trial, Roche data
30%
Dietary fat absorption blocked per dose
Xenical prescribing information
25+ years
Years of clinical use and safety data
FDA approval 1999
4 years
Longest continuous safety study
XENDOS 4-year trial
How It Works
Mechanism of Action
Orlistat at 120mg inhibits gastrointestinal lipase enzymes, preventing approximately 30% of consumed dietary fat from being broken down and absorbed into the bloodstream. The blocked fat passes through the intestines and is excreted, creating a consistent caloric deficit from fat sources.
Dosage Guide
Always follow your prescribing physician's specific instructions. The schedule below is a general guide.
Taken during or within 1 hour after each fat-containing meal
Exceeding this dose does not increase efficacy
Must be taken at least 2 hours before or after Xenical to ensure absorption
Key Benefits
Side Effects
Common Side Effects
- Oily/fatty stools
- Oily discharge
- Increased frequency of bowel movements
- Faecal urgency
- Flatulence with oily discharge
- Abdominal pain and discomfort
Rare but Serious
- Severe liver injury
- Kidney disease (oxalate nephropathy)
- Severe skin reactions
- Pancreatitis
Seek immediate medical attention if you experience any serious adverse effects.
Frequently Asked Questions
Who Is This For?
- Adults with BMI ≥30 kg/m²
- Adults with BMI ≥27 kg/m² with associated health risk factors
- Long-term obesity management alongside lifestyle changes
- Adults who cannot tolerate or are not suitable for GLP-1 therapies
Not Suitable For
- Chronic malabsorption syndrome
- Cholestasis
- Pregnancy
- Patients taking immunosuppressants (cyclosporine)
Starting from
$57.99
$0.69/capsule
Reviewed by a licensed US physician
How It Works
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