Orlistat
Orlistat 120mg
by Various generic manufacturers
Prescription-strength fat blocker — proven, affordable, and widely available
10.6 kg
Average weight loss at 1 year vs 6.1kg placebo
XENDOS trial, Diabetes Care 2004
30%
Dietary fat blocked from absorption at 120mg dose
Orlistat pharmacology studies
37%
Reduction in risk of developing type 2 diabetes
XENDOS trial 4-year data
4 years
Long-term safety data (XENDOS trial)
Diabetes Care 2004
How It Works
Mechanism of Action
Orlistat inhibits gastrointestinal and pancreatic lipase enzymes with high potency at the 120mg dose, preventing approximately 30% of consumed dietary fat from being absorbed. The undigested fat is eliminated through normal bowel movements.
Dosage Guide
Always follow your prescribing physician's specific instructions. The schedule below is a general guide.
Take one 120mg capsule with water during or up to 1 hour after each main meal containing fat
Do not exceed 3 doses per day. Skip dose if meal is fat-free or if a meal is missed
Take a fat-soluble vitamin supplement at bedtime, at least 2 hours apart from orlistat doses
Key Benefits
Side Effects
Common Side Effects
- Oily discharge from rectum
- Oily/fatty stools
- Increased bowel movements
- Faecal urgency
- Oily spotting on clothing
- Flatus (gas) with discharge
- Abdominal discomfort
Rare but Serious
- Severe liver injury (very rare)
- Kidney stones/oxalate nephropathy
- Cholelithiasis (gallstones)
- Elevated liver enzymes
Seek immediate medical attention if you experience any serious adverse effects.
Frequently Asked Questions
Who Is This For?
- Adults with BMI ≥30 kg/m²
- Adults with BMI ≥27 kg/m² with weight-related risk factors
- Long-term weight management under physician supervision
- As part of a structured reduced-calorie programme
Not Suitable For
- Patients with chronic malabsorption syndrome
- Cholestasis
- Pregnancy or breastfeeding
- Patients taking cyclosporine
Starting from
$49.99
$0.60/capsule
Reviewed by a licensed US physician
How It Works
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