Mysimba
Naltrexone/Bupropion
by Orexigen Therapeutics
Effective oral appetite control for patients who prefer tablets over injections
6.4%
Average placebo-adjusted weight loss
COR-I trial, Lancet 2010
55%
Patients achieved ≥5% weight loss
COR-I trial, Lancet 2010
28%
Patients achieved ≥10% weight loss
COR-I trial, Lancet 2010
56 weeks
Primary endpoint duration
COR-I trial, Lancet 2010
How It Works
Mechanism of Action
Mysimba combines two mechanisms: bupropion stimulates POMC (pro-opiomelanocortin) neurons in the hypothalamus to reduce appetite, while naltrexone blocks opioid receptors that would normally suppress POMC activity. Together, they create a sustained reduction in hunger and food cravings, particularly for high-reward foods.
Dosage Guide
Always follow your prescribing physician's specific instructions. The schedule below is a general guide.
Initiation — one 8mg/90mg tablet each morning
Second dose added in the evening
Third daily tablet added to morning dose
Full maintenance dose — 32mg/360mg daily total
Key Benefits
Side Effects
Common Side Effects
- Nausea
- Headache
- Constipation
- Dizziness
- Insomnia
- Dry mouth
- Vomiting
- Increased blood pressure
Rare but Serious
- Seizures (rare but serious)
- Suicidal thoughts (black box warning — monitor closely)
- Liver damage (rare)
- Hypersensitivity reactions
Seek immediate medical attention if you experience any serious adverse effects.
Frequently Asked Questions
Who Is This For?
- Adults with BMI ≥30 kg/m²
- Adults with BMI ≥27 kg/m² with weight-related comorbidities
- Patients who prefer oral tablets to injections
- Patients with emotional or compulsive eating patterns
Not Suitable For
- Patients currently using opioids or in opioid withdrawal
- Patients with uncontrolled hypertension
- History of seizure disorder
- Patients taking MAOIs
- Pregnancy or breastfeeding
- Patients with eating disorders (anorexia/bulimia)
Starting from
$115.00
$1.03/tablet
Reviewed by a licensed US physician
How It Works
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Ready to Start Your Mysimba Journey?
A licensed US physician will review your consultation, answer all your questions, and prescribe if you're eligible — all from the comfort of home.
No commitment · Reviewed within 24 hours · HIPAA-compliant