alli
Orlistat 60mg
by Haleon (GSK Consumer Healthcare)
The only FDA-approved over-the-counter weight loss treatment — no prescription required
5.1 kg
Average weight loss at 12 months (diet + alli vs diet alone)
FDA approval studies, 2007
25%
Of consumed dietary fat blocked from absorption
Orlistat pharmacology data
50%
More weight lost vs diet alone
Comparative clinical data
1973
FDA-approved since (prescription version)
FDA approval database
How It Works
Mechanism of Action
Orlistat inhibits pancreatic and gastric lipase — the enzymes responsible for breaking down dietary fat. When these enzymes are blocked, fat cannot be digested and absorbed. Instead, approximately 25% of consumed fat passes through the digestive system undigested and is excreted.
Dosage Guide
Always follow your prescribing physician's specific instructions. The schedule below is a general guide.
Take one capsule with water with each main meal containing fat, or within 1 hour after the meal
Do not exceed 3 capsules per day. If a meal is skipped or contains no fat, skip the dose
Fat intake per meal should be no more than 30% of calories. High-fat meals cause significant GI side effects
Key Benefits
Side Effects
Common Side Effects
- Oily/spotting discharge
- Frequent or hard-to-control bowel movements
- Oily stools
- Oily spotting on underwear
- Gas with discharge
- Stomach pain
Rare but Serious
- Liver injury (rare — report yellowing of skin/eyes)
- Kidney stones
- Pancreatitis
- Rectal bleeding
Seek immediate medical attention if you experience any serious adverse effects.
Frequently Asked Questions
Who Is This For?
- Adults aged 18+ with BMI ≥25 kg/m²
- As an adjunct to a reduced-calorie, lower-fat diet
- Patients who prefer a non-prescription option
- Patients with mild to moderate overweight
Not Suitable For
- Patients with cholestasis or malabsorption syndrome
- Patients on anticoagulants (warfarin) without monitoring
- Pregnancy or breastfeeding
- Patients with known kidney stones or hyperoxaluria
Starting from
$39.50
$0.47/capsule
Reviewed by a licensed US physician
How It Works
You Might Also Consider
Wegovy
Average 21% body weight loss — the gold standard in medically supervised weight loss
Mounjaro
Up to 22.5% body weight loss — the most effective weight loss medication in clinical history
Nevolat
The affordable liraglutide option — same proven GLP-1 mechanism as Saxenda at a lower cost
Ready to Start Your alli Journey?
A licensed US physician will review your consultation, answer all your questions, and prescribe if you're eligible — all from the comfort of home.
No commitment · Reviewed within 24 hours · HIPAA-compliant